What Is a Tandem Transplant and What Are the Benefits?

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In this “Ask the Expert” segment featuring Dr. Gareth Morgan from the University of Arkansas for Medical Sciences, a Patient Power community member wants to know more about tandem transplant.  Dr. Morgan responds with an explanation of tandem transplant and the long-term outcomes of a double transplant for myeloma patients.

Clinical Trials Mentioned in This Video

Stem Cell Transplant Clinical Trials

This Ask the Expert series is sponsored by the Patient Empowerment Network, which received funding from Celgene.

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Transcript

Please remember the opinions expressed on Patient Power are not necessarily the views of our sponsors, contributors, partners or Patient Power. Our discussions are not a substitute for seeking medical advice or care from your own doctor. That’s how you’ll get care that’s most appropriate for you.          

Andrew Schorr:

Ok, Dr. Orlowski. Here is a two-part question from Rashmi. Rashmi wants to know, “What is a tandem transplant? And what are the benefits over a single transplant?”

Dr. Morgan:

So for patients it's always important to remember the difference between an auto transplant and an allo [allogeneic] transplant, and an allo is where you have a donor transplant from somebody else.  Those haven't really worked out up to now in myeloma, and a lot of effort has gone into making auto transplants work.  

Traditionally, a single transplant has been used, but in certain countries and certain centers the tandem transplant, which is two transplants given close together to maximize the impact of the high doses of chemotherapy that you can give.  And if you really look hard at the data I think there's more than enough evidence to justify using a double tandem transplant rather than a single one.  It seems that long term at the tails of the curves seem to come up, so my view is that the double transplant, the tandem transplant is the way to go.  People tolerate them, and the long?term outcomes are better. 

Please remember the opinions expressed on Patient Power are not necessarily the views of our sponsors, contributors, partners or Patient Power. Our discussions are not a substitute for seeking medical advice or care from your own doctor. That’s how you’ll get care that’s most appropriate for you. 

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Page last updated on July 17, 2017