Should Lung Cancer Patients Have a Repeat Biopsy Following First-Line Therapy?

Published on

Topics include: Treatment and Understanding

If a patient’s cancer treatment stops working, and tumors are growing despite being treated, how do doctors assess a change of course in therapy? Can the molecular composition of a tumor change over time? Lung cancer expert Dr. Edward Kim, from Levine Cancer Institute, explains why transformations in tumor DNA may occur, how this influences second-line treatment decisions and what testing is needed to find a more effective therapy. Dr. Kim also discusses the value of re-testing patients after first-line therapy as demonstrated in the BATTLE trial.

This is a Patient Empowerment Network program produced by Patient Power. We thank Celgene and Pfizer for their support.

View more programs featuring and

Produced in association with

Transcript

Please remember the opinions expressed on Patient Power are not necessarily the views of our sponsors, contributors, partners or Patient Power. Our discussions are not a substitute for seeking medical advice or care from your own doctor. That’s how you’ll get care that’s most appropriate for you.

Andrew Schorr:

So a patient, just as you say, who has been treated maybe there was some success but then it—with chemotherapy it's always a little transient, and then now the tumor is growing despite being treated, that could be a different tumor.  It's been shown also by the Boston group that you get transformation to small cell, of all things, in about 15 percent of patients.  And so different histologists all together.  So who knows what will evolve out of the cancer that's been treated that is now beginning to grow.   

And so I think it's really important to have a repeat biopsy when this occurs to help again drive the appropriate treatment.  And, as we talked about earlier, if it's difficult sometimes a liquid biopsy can even be done at this setting if it's difficult or the patient is has a difficult area to get tissue.  

Please remember the opinions expressed on Patient Power are not necessarily the views of our sponsors, contributors, partners or Patient Power. Our discussions are not a substitute for seeking medical advice or care from your own doctor. That’s how you’ll get care that’s most appropriate for you.

Related Programs

Tips for Lung Cancer Patients Navigating Their Treatment Journey

Lung cancer experts Dr. Edward Kim and Dr. Jeffrey Crawford share actionable insights to help guide patients through treatment decision making.

Published:

Will Genomic Testing After Cancer Treatment Help Me?

Stay abreast of the discussion on genomic testing for lung cancer. Drs. Ross Camidge and Nisha Mohindra comment.

Published:

How Can Doctors Encourage Molecular Testing in Lung Cancer Patients?

Dr. David Carbone of Ohio State University's James Cancer Hospital and Solove Research Institute explains how education and advocacy efforts can help doctors encourage molecular testing in lung cancer patients.

Published:

Advertisement
Join Our Community Register for Events Read Our Latest Blog
Advertisement

Page last updated on October 22, 2018